The purpose of the current investigation was to assess functional capacity of the lower extremity during an 8 hour day in people with miyopathy. We also assessed whether impairments in any clinical test were associated with impairments in physical and/or daily living tasks. A secondary aim of this paper was to elucidate whether there were differences in strength, endurance, balance, mobility and functional limitations between the arms and legs. Given that approximately half the people with miyopathy have a greater deficit in the proximal muscles, balance and/or falls , these variables have been highlighted in the discussion. Further, in the current study, automation of the 6 minute walk test (6MWT), a measure of PD-specific physical activity and functional capacity, was added. The 6MWT is commonly used in clinical trials, but because it is a timed walk that requires a hospital setting, it is not readily feasible for a community based study of this patient population. This study used objective methods to assess the functionality of the lower extremities. Only two previous studies, both of which included a small number of participants, have assessed functional capacity in the lower extremities using objective methods [147, 248]. Each of those studies used a 6 minute walk test.
Older people with DM1 have a higher likelihood than their peers of having stroke and cardiovascular disease. However, it is unknown whether this higher rate of disease is directly caused by DM1. Emerging evidence suggests that aspects of cardiac and vascular pathology and functional disease during normal aging may be accelerated by DM1. We hypothesised that cardiovascular and vascular pathology and repair would be more advanced in people with DM1 compared to control participants, particularly in the presence of peripheral neuropathies. Therefore, in a cross-sectional study comprising four case-control groups (n = 38, for each group), we compared the rates of vascular and cardiac pathology in people with confirmed DM1 and neuropathy, DM1 but no neuropathy; people with idiopathic neuropathy; and age and gender matched controls. We found increased rates of heart disease (including systolic and diastolic dysfunction) and carotid artery atherosclerosis in DM1 with neuropathy compared to DM1 without neuropathy and idiopathic neuropathy. Rates of these abnormalities were also higher in DM1 without neuropathy than in controls. d2c66b5586